Second BPAN disease symposium in France
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Second BPAN disease symposium in France
The University of Bordeaux, the Association Autour du BPAN gather to organize the second symposium on BPAN disease in Bordeaux, France. This international symposium will bring together patient organization, scientific and medical experts to share the latest research in the field and to foster networking opportunities on BPAN disease research.
Invited Speakers
Tassula Proikas-Cezanne
Department of Molecular Biology, Interfaculty Institute for Cell Biology, University of Tuebingen, Germany
Rosaria Ingrassia
Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia Brescia, Italy
Rachel Wise
Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia Brescia, Italy
Bertand Mollereau
Laboratory of Biology and Modelling of the Cell – CNRS : UMR5239, INSERM U2110, Université de Lyon, ENS de Lyon, UMS344 Biosciences Lyon Gerland - France
Prof Bertrand Mollereau is the head of the “Regulated Cell Death and Genetics of Neurodegeneration” at the Laboratory of Biology and Modelling of the Cell of the ENS of Lyon. In 2017, he was nominated senior member of the Institut Universitaire de France, a prestigious recognition of his scientific career. B. Mollereau is an international expert on neurodegeneration, autophagy, ER stress and Parkinson’s disease, topics on which he published more than 60 publications. In 2019, his group initiated a research project on BPAN using Drosophila as model to study the importance of autophagy and ER stress.
Organizing Committee
Chloé Angelini
Geneticist, University of Bordeaux, College of Health Science
Member of the scientific council of the association Autour du BPAN, Professor Gaëtan LESCA is a geneticist at the Hospices Civils de Lyon and professor of genetics at the Lyon Est faculty (Université Claude Bernard Lyon 1). It is involved in the genetic diagnosis of neurodevelopment disorders and in particular epilepsies, brain malformations and intellectual disabilities. He also carries out research activities at the CHU and within the NeuroMyoGène Institute. He has contributed to the identification of several genes involved in these diseases and to numerous works on the characterization of genotype-phenotype correlations.
Isabelle Coupry
Researcher, CR / Inserm, Translational research on neurogenetic diseases (NRGEN), INCIA
cPr. Bertrand Mollereau is the head of the Apoptosis and Neurogenetics group at the Laboratory of Molecular Biology of the Cell at Ecole Normale Supérieure de Lyon (ENSL). In 1997, Dr. Mollereau received his Ph.D. on Immunology from the University of Paris XI in the laboratory of Anna Senik. He then conducted post-doctoral research with Dr. Claude Desplan in the Laboratory of Molecular Genetics at Rockefeller and New York Universities. In 2001, Dr. Mollereau was appointed Research Assistant Professor in the Strang Laboratory of Apoptosis and Cancer Biology under Dr. Hermann Steller at the Rockefeller University, USA. There, he obtained NIH grant support and headed a junior research group to study photoreceptor development and apoptosis in Drosophila. Dr. Mollereau joined the faculty as professor at the Ecole Normale Supérieure de Lyon in autumn 2006. In 2008, his group was awarded the ATIP (CNRS) and Fondation pour la Recherche Medical Equipe programmes. His group is interested in understanding the mechanism of cell death and pathophysiology of neurodegenerative diseases using Drosophila and mouse models.
Christelle Durand
Research Engineer, University of Bordeaux, College of Health Science,
Translational research on neurogenetic diseases (NRGEN), INCIA
Translational research on neurogenetic diseases (NRGEN), INCIA
Ludivine Walter is an Assistant Professor at Claude Bernard Lyon 1 University. She received her Ph. D in Physiology, Nutrition and Physiopathology from Paris VII University under the mentorship of Pr Eric Fontaine. Immediately following her Ph. D, she completed a post doctoral training in Pr. Gyorgy Hajnoczky's lab at the Jefferson Medical School inm Philadelphia, USA. Subsequently, she started using model organism in Pr Sylvia Lee's lab at Cornell University, Ithaca, USA, where she was awarded a United Mitochondrial Disease Fellowship to work on mitochondria in aging processes in the nematode C. elegans. An ERG Marie Curie fellowship allowed to pursue her research in Hugo Aguilaniu's lab. She joined Bertrand Mollereau's lab in 2016 to study the role of the mitochondria in cell death and physiopathology. She teaches undergraduate and graduate classes in molecular biology and genetics.
Patricia Fergelot
University of Bordeaux, College of Health Science | CHU Bordeaux · Developmental Abnormalities and Malformative Syndromes Reference Centre, MD, PhD
Ludivine Walter is an Assistant Professor at Claude Bernard Lyon 1 University. She received her Ph. D in Physiology, Nutrition and Physiopathology from Paris VII University under the mentorship of Pr Eric Fontaine. Immediately following her Ph. D, she completed a post doctoral training in Pr. Gyorgy Hajnoczky's lab at the Jefferson Medical School inm Philadelphia, USA. Subsequently, she started using model organism in Pr Sylvia Lee's lab at Cornell University, Ithaca, USA, where she was awarded a United Mitochondrial Disease Fellowship to work on mitochondria in aging processes in the nematode C. elegans. An ERG Marie Curie fellowship allowed to pursue her research in Hugo Aguilaniu's lab. She joined Bertrand Mollereau's lab in 2016 to study the role of the mitochondria in cell death and physiopathology. She teaches undergraduate and graduate classes in molecular biology and genetics.
Cyril Goizet
Team Leader, PU-PH / University of Bordeaux, College of Health Science, Translational research on neurogenetic diseases (NRGEN), INCIA
Ludivine Walter is an Assistant Professor at Claude Bernard Lyon 1 University. She received her Ph. D in Physiology, Nutrition and Physiopathology from Paris VII University under the mentorship of Pr Eric Fontaine. Immediately following her Ph. D, she completed a post doctoral training in Pr. Gyorgy Hajnoczky's lab at the Jefferson Medical School inm Philadelphia, USA. Subsequently, she started using model organism in Pr Sylvia Lee's lab at Cornell University, Ithaca, USA, where she was awarded a United Mitochondrial Disease Fellowship to work on mitochondria in aging processes in the nematode C. elegans. An ERG Marie Curie fellowship allowed to pursue her research in Hugo Aguilaniu's lab. She joined Bertrand Mollereau's lab in 2016 to study the role of the mitochondria in cell death and physiopathology. She teaches undergraduate and graduate classes in molecular biology and genetics.
Jean-Paul Lasserre
MCU, University of Bordeaux, College of Health Science, Translational research on neurogenetic diseases (NRGEN), INCIA
Ludivine Walter is an Assistant Professor at Claude Bernard Lyon 1 University. She received her Ph. D in Physiology, Nutrition and Physiopathology from Paris VII University under the mentorship of Pr Eric Fontaine. Immediately following her Ph. D, she completed a post doctoral training in Pr. Gyorgy Hajnoczky's lab at the Jefferson Medical School inm Philadelphia, USA. Subsequently, she started using model organism in Pr Sylvia Lee's lab at Cornell University, Ithaca, USA, where she was awarded a United Mitochondrial Disease Fellowship to work on mitochondria in aging processes in the nematode C. elegans. An ERG Marie Curie fellowship allowed to pursue her research in Hugo Aguilaniu's lab. She joined Bertrand Mollereau's lab in 2016 to study the role of the mitochondria in cell death and physiopathology. She teaches undergraduate and graduate classes in molecular biology and genetics.
Giovanni Stevanin
Team Leader DR / Inserm / Translational research on neurogenetic diseases (NRGEN) , INCIA
Ludivine Walter is an Assistant Professor at Claude Bernard Lyon 1 University. She received her Ph. D in Physiology, Nutrition and Physiopathology from Paris VII University under the mentorship of Pr Eric Fontaine. Immediately following her Ph. D, she completed a post doctoral training in Pr. Gyorgy Hajnoczky's lab at the Jefferson Medical School inm Philadelphia, USA. Subsequently, she started using model organism in Pr Sylvia Lee's lab at Cornell University, Ithaca, USA, where she was awarded a United Mitochondrial Disease Fellowship to work on mitochondria in aging processes in the nematode C. elegans. An ERG Marie Curie fellowship allowed to pursue her research in Hugo Aguilaniu's lab. She joined Bertrand Mollereau's lab in 2016 to study the role of the mitochondria in cell death and physiopathology. She teaches undergraduate and graduate classes in molecular biology and genetics.
Program
Day One, Clinical and scientific program (in English)
Friday, May 12th, 2023
CHECK-IN
Check-in and coffee
9:00am - 9:30am
Autour du BPAN
Introduction
9:30am - 9:45am
Tassula Proikas-Cezanne (Allemagne)
9:45am - 10:30am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Olivier Vincent (IIB, Madrid, Spain)
Objet de la presentation
11:45am - 12:15am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Coffee Break
10:30am - 11:00am
Marion Celle (ENS Lyon, France)
Establishing a Drosophila model of BPAN disease
11:00am - 11:45am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Francine Coté (Cochin Institute, Paris, France)
Study of the role of serotonin in the control of ferritinophagy and its therapeutic application to BPAN
11:45am - 12:15pm
The WDR45 gene is localized on the X-chromosome and different variants in this gene are causative for the neurodegenerative disorder BPAN (ß-propeller protein associated neurodegeneration). WDR45/WIPI4 is a WD-repeat β-propeller protein that belongs to the WIPI (WD repeat domain, phosphoinositide interacting) family. The precise cellular function of WDR45 is still largely unknown, but deletions or variants in WDR45 can lead to macroautophagy/autophagy defects, malfunctioning mitochondria, endoplasmic reticulum stress and unbalanced iron homeostasis, suggesting that this protein functions in one or more pathways regulating directly or indirectly those processes. Our laboratory is studying the molecular functions of WDR45, particularly in autophagy and mitochondrial homeostasis, using a variety of cellular systems.
Lunch Break
12:30pm – 2:30pm
12 Grand Maurian, 33000 Bordeaux
Autour du BPAN
Introduction
2:15pm - 2:30pm
Rosaria Ingrassia (Milan, Italy)
Ferrous iron is up-regulated and starvation-dependent in fibroblasts of patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN)
2:30pm – 3:15pm
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Rachel Wise (Germany)
Vicious cycle of iron dyshomeostasis and dopamine oxidation in iPSC-derived dopaminergic neurons from BPAN patients
3:15pm – 4:00pm
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Coffee Break
4:00pm – 4:30pm
Jean-Paul Lasserre (Bordeaux, France)
The yeast Saccharomyces cerevisiae used as a tool and model in the pathology of BPAN
4:30pm – 5:15pm
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
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Synthesis
Objet de la presentation
5:15pm
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
To Be Announced
Objet de la presentation
5:45pm – 6:15pm
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
End of first day
06:00pm
Gala Evening
Wine tasting at 3 Montbazon
3 rue Montbazon 33000 Bordeaux
General discussion
Presentation of the Bordeaux vineyard by Nicolas Tissier (Sommelier)
8:00pm
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Gala Dinner at 3 Montbazon
3 rue Montbazon 33000 Bordeaux
Day Two, Families program (in French)g
Saturday, May 13th, 2023
CHECK-IN
Check-in and Coffee
8:15am - 8:30am
Autour du BPAN
Introduction
8:45am - 8:55am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Research (in French)
Bertrand Mollereau (ENS Lyon, France))
Is the restoration of autophagy a promising therapeutic strategy for BPAN disease?
8:55am - 9:20am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Francine Coté (Institue Cochin, Paris, France)
9:20am - 9:45am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Jean-Paul Lasserre (CHU Bordeaux, France)
9:45am - 10:10am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Coffee Break
10:10am - 10:40am
The National Protocol for Diagnosis and Care (Le Protocole Nationnal de Diagnostic et de Soins PNDS) (in French)
Lunch on your ownf
12:30pm – 2:00pm
Gaetan Lesca (HCL, Lyon, France)
10:40am – 11:05am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Alexandra Benchoua/Joanna Tournois (I-Stem, Evry, France)
Objet de la presentation
11:30am – 12:00am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
Chloé Angelini (CHU Bordeaux, France)
11:05am – 11:30am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
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Summary of the previous day
General discussion
11:30am – 12:00am
Understanding the fundamentals of Supplemental Security Income (SSI), Social Security Disability Insurance (SSDI), Childhood Disabled Beneficiary Benefits (CDB), Medi-Cal, Medicare, Regional Center, and In Home Supportive Services (IHSS) is the critical first step for the professional to know how to properly plan for persons with disabilities and how to manage their personal and financial care during their lifetimes. This is the foundational program to all other programs. It is a must see for the beginner and an excellent refresher for the experienced professional.
End of meeting
12:00am
Registration
Registration rate
Registration for this year's symposium costs 45.00€ for the first day, optionnaly 45.00€ for the gala diner (valid only for people registered on the first day) and 12.00€ for the second day (price in euros) for all.
Registration must be done online. Registration until April 30th.
Payments can be made online by card (Mastercard/VISA), PayPal, by bank transfers or cheque after etablishing a purchase order using the registration form that will be below.
Registration for this year's symposium costs 45.00€ for the first day, optionnaly 45.00€ for the gala diner (valid only for people registered on the first day) and 12.00€ for the second day (price in euros) for all.
Registration must be done online. Registration until April 30th.
Payments can be made online by card (Mastercard/VISA), PayPal, by bank transfers or cheque after etablishing a purchase order using the registration form that will be below.
Step One: Verify your identity. To access the registration form, you must enter a valid email. A verification code will be sent to this email.
Step Two: Complete the form below to order.
Step Tree: Choose your payment method.
Direct payment: By paypal or Credit Cards
Place Order: Your can download this purchase order - payment can be made by bank transfer or bank check before April 29th
Generate the purchase Order
Registration from 15 March 2023.
Information
Please fill the form below for more informations on the program and registration.
Extended abstract deadline submission April 11th
Extended abstract deadline submission April 11th
Access map
The symposium will take place at amphitheater 7, on the Site Carreire de l'Universsité de Bordeaux, located 146, rue Léo Saignat 33076 Bordeaux cedex.
FROM BORDEAUX AIRPORT (50 to 60 minutes)
1. At the Airport stop, take the Liane 1 towards Quinconces
2. Get off at the Lycées de Mérignac stop.
3. At the Lycées de Mérignac stop, take Tramway Line A towards La Gardette - Bassens - Carbon-Blanc
4. Get off at François Mitterrand. (See the walking route from this stop on the proximity maps below).
1. At the Airport stop, take the Liane 1 towards Quinconces
2. Get off at the Lycées de Mérignac stop.
3. At the Lycées de Mérignac stop, take Tramway Line A towards La Gardette - Bassens - Carbon-Blanc
4. Get off at François Mitterrand. (See the walking route from this stop on the proximity maps below).
FROM THE TRAIN STATION (GARE SAINT JEAN) (15 TO 20 MINUTES)
Take Tramway Line C direction Les Aubiers to the Porte de Bourgogne stop; Take Tramway Line A direction Mérignac Centre,
Get off at the François Mitterrand stop. (See the walking route from this stop on the proximity maps below)
Take Tramway Line C direction Les Aubiers to the Porte de Bourgogne stop; Take Tramway Line A direction Mérignac Centre,
Get off at the François Mitterrand stop. (See the walking route from this stop on the proximity maps below)
BY CAR, FROM PARIS:
1. Follow the direction: BORDEAUX-CENTRE / GARE SAINT-JEAN, then BOULEVARDS,
2. Pass the barriers of Bègles, Toulouse, St Genès and Pessac,
3. Then follow signs for Université Bordeaux 2 (on the left).
BY CAR, FROM TOULOUSE:
1. Follow the direction: BASSIN D'ARCACHON / MÉRIGNAC / PESSAC / VILLENAVE-D'ORNON,
2. Exit at exit n°16, then follow the direction TALENCE-CENTRE / DOMAINE UNIVERSITAIRE,
3. Arrived on the Boulevards follow (left) CHU Pellegrin and pass the barriers of St Genès, then Pessac, then follow University Bordeaux 2 (on the left).
1. Follow the direction: BORDEAUX-CENTRE / GARE SAINT-JEAN, then BOULEVARDS,
2. Pass the barriers of Bègles, Toulouse, St Genès and Pessac,
3. Then follow signs for Université Bordeaux 2 (on the left).
BY CAR, FROM TOULOUSE:
1. Follow the direction: BASSIN D'ARCACHON / MÉRIGNAC / PESSAC / VILLENAVE-D'ORNON,
2. Exit at exit n°16, then follow the direction TALENCE-CENTRE / DOMAINE UNIVERSITAIRE,
3. Arrived on the Boulevards follow (left) CHU Pellegrin and pass the barriers of St Genès, then Pessac, then follow University Bordeaux 2 (on the left).
OUR PARTNERS
Autour du BPAN
French Association law 1901, recognized of general interest
OUR Coordinates
Autour du BPAN
1610, CHEMIN DES GRANGES
42155 OUCHES
FRANCE
Tel. : +33 (0)6 87 25 92 45
Siren Number 841 375 512
1610, CHEMIN DES GRANGES
42155 OUCHES
FRANCE
Tel. : +33 (0)6 87 25 92 45
Siren Number 841 375 512
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